Shopping Cart

Your shopping cart is currently empty

Amtolmetin guacil

Name: Amtolmetin guacil
Brand: TargetMol
SKU: T19672
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T19672Cas No. 87344-06-7

Alias ST-679, ST679, ST 679, MED-15, MED15, MED 15

Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.

Amtolmetin guacil

Copy Product Info

🥰Excellent

Purity: 99.85%

Catalog No. T19672Alias ST-679, ST679, ST 679, MED-15, MED15, MED 15Cas No. 87344-06-7

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$100	In Stock	In Stock
100 mg	$148	In Stock	In Stock
500 mg	$329	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Amtolmetin guacil AI Summary

Amtolmetin guacil inhibits the production of nitric oxide (NO) induced by LPS/IFNgamma in mouse RAW264.7 cells, with an IC50 value of 51300.0 nM determined by the Griess reagent method after 24 hours of treatment. It also exhibits antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in various cell lines. Specifically, it inhibits cytotoxicity of Caco-2 cells at 10 µM after 48 hours with 0.41% inhibition, and VERO-6 cells at the same concentration and duration with -0.05% inhibition. Additionally, Amtolmetin guacil inhibits the SARS-CoV-2 3CL-Pro protease by 7.964% at 20 µM. This compound also shows inhibitory effects on human HDAC6 enzyme activity, with 27.41% inhibition using a commercial peptide substrate, but exhibits a -1.33% inhibition when a custom peptide substrate is used, suggesting variability in its efficacy depending on the assay conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
Synonyms	ST-679, ST679, ST 679, MED-15, MED15, MED 15

Chemical Properties

Molecular Weight	420.46
Formula	C₂₄H₂₄N₂O₅
Cas No.	87344-06-7
Smiles	COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
Relative Density.	1.19 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (142.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3783 mL	11.8917 mL	23.7835 mL	118.9174 mL
5 mM	0.4757 mL	2.3783 mL	4.7567 mL	23.7835 mL
10 mM	0.2378 mL	1.1892 mL	2.3783 mL	11.8917 mL
20 mM	0.1189 mL	0.5946 mL	1.1892 mL	5.9459 mL
50 mM	0.0476 mL	0.2378 mL	0.4757 mL	2.3783 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1892 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc